Levodopa responsiveness in Parkinson’s disease patients and white matter alterations in diffusion tensor imaging: a cross-sectional tract-based spatial statistics study

This study aimed to investigate the relationship between levodopa responsiveness and white matter alterations in Parkinson’s disease patients using diffusion tensor imaging (DTI). Twenty-six recruited Parkinson’s disease patients were evaluated using the Mini-Mental State Examination, Hoehn and Yahr scale (H&Y) and Unified Parkinson’s Disease Rating Scale (UPDRS). Each patient underwent a DTI scan and an acute levodopa challenge test. The improvement rate of UPDRS-III was calculated, Parkinson’s disease patients were grouped into a responsive group (improvement rate ≥30%) and a nonresponsive group (improvement rate
Source: NeuroReport - Category: Neurology Tags: Clinical Neuroscience Source Type: research