HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2

ConclusionsThese results suggest that HBx-ETS1-CDK2-UHRF2 pathway plays an important role in the pathogenesis of HBV-associated HCC and represents new therapeutic targets for human HCC.Clinical Trials RegistrationChiCTR2000041416.
Source: Hepatology International - Category: Infectious Diseases Source Type: research