Evaluation of fertility outcome as a consequence of intravaginal inoculation with sperm impairing microorganisms in mouse model.

Evaluation of fertility outcome as a consequence of intravaginal inoculation with sperm impairing microorganisms in mouse model.
J Med Microbiol. 2015 Feb 9;
Authors: Vander H, Prabha V
Abstract
The concept of infertility as a result of asymptomatic microbial colonization of female reproductive tract has been neglected till date. However, increasing incidence of infertility and advanced research has drawn attention towards this idea. Many of these microorganisms have been reported to bring adverse changes in sperm parameters in vitro, but their in vivo potential to cause infertility is still a controversy. The present study was carried out to observe what effect the intravaginal inoculation of spermagglutintaing Serratia marcescens and sperm immobilizing Candida albicans may have in reproductive tract and consequently in fertility outcome. When these strains were intravaginally inoculated into female Balb/c mice at concentrations of 104, 106,108 cfu for 10 consecutive days and mating of mice on day 12, the result showed 100% decrease in fertility in all the groups as compared to control mice receiving PBS. Further, no clinical or histopathological changes were observed in reproductive organs viz. ovary, uterus and vagina suggesting that colonization of genital tract with sperm impairing microorganisms could be a feasible reason for female infertility.
PMID: 25666839 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - February 9, 2015 Category: Microbiology Authors: Vander H, Prabha V Tags: J Med Microbiol Source Type: research