Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular A β1-42 rat model of Alzheimer's disease through modulations of hippocampal cAMP/cGMP/BDNF signaling pathway

CONCLUSION: The outcomes of the current study indicate that RFM and TDF lead to memory enhancement through upregulation of cAMP/cGMP/BDNF pathway, thus they may have a therapeutic potential in cognitive deficits associated with AD.PMID:33860460 | DOI:10.1007/s43440-021-00264-w
Source: Pharmacological Reports - Category: Drugs & Pharmacology Authors: Source Type: research