Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL [Microbiology]

Helicobacter pylori, a pathogen responsible for gastric cancer, contains a unique glycolipid, cholesteryl-α-D-glucopyranoside (CGL), in its cell wall. Moreover, O-glycans having α1,4-linked N-acetylglucosamine residues (αGlcNAc) are secreted from gland mucous cells of gastric mucosa. Previously, we demonstrated that CGL is critical for H. pylori survival and that αGlcNAc serves as...

Source: Proceedings of the National Academy of Sciences - April 14, 2021 Category: Science Authors: Junichi Kobayashi, Masatomo Kawakubo, Chifumi Fujii, Nobuhiko Arisaka, Masaki Miyashita, Yoshiko Sato, Hitomi Komura, Hisanori Matoba, Jun Nakayama Tags: Microbiology Biological Sciences Source Type: research