Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs)

ConclusionsThis study demonstrated that HPD was related to the number of  prior metastatic sites >  2, liver metastasis, RMH score ≥ 2, higher ECOG PS score and LDH >  ULN. Moreover, HPD was correlated with a poor OS and PFS in patients following ICI therapy.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research