Invasive ACTH-Producing Pituitary Gland Neoplasm Secondary to MSH2 Mutation

Germline mutations in mismatch repair (MMR) genes MSH2, MLH1, MSH6, PMS2 and EPCAM are responsible for Lynch syndrome, a hereditary cancer-predisposition disorder also known as hereditary non-polyposis colorectal cancer (HNPCC). These genes have roles in repairing errors in DNA that can arise during replication.

Source: Cancer Genetics and Cytogenetics - April 4, 2021 Category: Genetics & Stem Cells Authors: PB Loughrey, G Baker, B Herron, S Cooke, D Iacovazzo, JR Lindsay, M Korbonits Source Type: research