A deleterious interplay between Endoplasmic reticulum stress and its functional linkage to Mitochondria in nephrolithiasis

In conclusion, our data showed that hyperoxaluria induces renal ER stress which triggers mitochondria dysfunction, might be via alteration in the sigma-1 receptor protein in the mitochondria-associated ER membranes, which leads to apoptosis, renal injury, and calcium oxalate crystal deposition.PMID:33798617 | DOI:10.1016/j.freeradbiomed.2021.03.031
Source: Free Radical Biology and Medicine - Category: Biology Authors: Source Type: research