Decreased amino acids in the brain might contribute to the progression of diabetic neuropathic pain

Diabetic peripheral neuropathy is one of the most frequent complications of diabetes mellitus (DM)[1], and approximately 61.8% of patients with DM develop diabetic peripheral neuropathy[2]. Up to 25% of patients with diabetic peripheral neuropathy develop diabetic neuropathic pain (DNP)[3], which is characterized by spontaneous pain, hyperalgesia, and allodynia. Compared with painless diabetic neuropathy, DNP significantly decreases the quality of life of patients with issues such as depression, anxiety, sleep disturbances, and reduced employability at work[4 –6].

Source: Diabetes Research and Clinical Practice - April 1, 2021 Category: Endocrinology Authors: Qi Zhang, Qingchun Li, Siying Liu, Hangping Zheng, Lijin Ji, Na Yi, Xiaoming Zhu, Wanwan Sun, Xiaoxia Liu, Shuo Zhang, Yiming Li, Qian Xiong, Bin Lu Source Type: research