Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography

Conclusion: These findings suggest that impaired integrity of dopaminergic nigrostriatal nerve terminals is associated with nigrostriatal axonal dysfunction in mild to moderate PD. Assessment of nigrostriatal tract integrity may be suitable as a biomarker of early- or even prodromal-stage PD.

Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Sanchez-Catasus, C. A., Bohnen, N. I., Yeh, F.-C., DCruz, N., Kanel, P., Muller, M. L. T. M. Tags: Clinical Source Type: research