Study reveals how long-term infection and inflammation impairs immune response as we age

(Texas Children's Hospital) A study published led by Dr. Katherine King, associate professor at Baylor College of Medicine and Texas Children's Hospital, shows for the first time that long-term infection and chronic inflammation drive CH mediated by the loss of Dnmt3a function. In addition, the study offers key insights into the mechanism by which chronic inflammation leads to CH and demonstrates the critical role of DNMT3a in regulating normal HSC responses to infections.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news