Prednisolone and Prednisone Pharmacokinetics in Adult Renal Transplant Recipients

Conclusions: The large interindividual variability in both PL exposure and suppression of endogenous CL implies a possible role for therapeutic drug monitoring. An abbreviated profile within the first 4 hours after PL dosing provides a good prediction of PL exposure in renal Tx recipients. The strong negative correlation between PL AUC0–24 and morning CL levels suggests a possible surrogate marker for drug exposure for further evaluation.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research