FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice

Obesity and osteoporosis frequently coexist, and might have a causal relationship. Gut microbiota, associated with both lipid and bone metabolism, plays an important role in the pathogenesis of excessive fat accumulation and bone loss. The improvement of intestinal flora by prebiotics was a promising strategy for ameliorating obesity-related bone loss.

Source: Metabolism - Clinical and Experimental - March 19, 2021 Category: Biomedical Science Authors: Zheng Zhang, Tao Lin, Yichen Meng, Miao Hu, Lun Shu, Heng Jiang, Rui Gao, Jun Ma, Ce Wang, Xuhui Zhou Source Type: research