Differences in coronary artery disease and outcomes of percutaneous coronary intervention with drug-eluting stents in women and men

Expert Rev Cardiovasc Ther. 2021 Mar 12. doi: 10.1080/14779072.2021.1902806. Online ahead of print.ABSTRACTINTRODUCTION: Despite common perceptions, coronary artery disease (CAD) is not a male-specific condition, and sex-based differences do occur in many aspects, including clinical outcomes after percutaneous coronary intervention (PCI) with stent implantation. New-generation drug-eluting stent (DES) significantly improved post-PCI outcomes. However, no sex-specific guidelines on PCI and the use of DES are available as current evidence was derived from clinical trials enrolling predominantly male patients.AREAS COVERED: This review aims at exploring sex-based disparities in CAD characteristics and manifestations, and comparing PCI outcomes and the efficacy and safety profiles of DES according to sex. In addition, a critical approach to trials' interpretation with an analysis of sources of bias is provided to inform future research and clinical practice.EXPERT OPINION: Sex gap in clinical outcomes after PCI with DES implantation is narrowing due to improved performances of new-generation DES. However, scientific research and biomedical engineering are striving to optimize DES profiles and generate new iterations of devices. At the same time, gender initiatives and sex-specific trials are accruing to overcome current issues in the field. Advances in these areas will foster improvements in early and long-term clinical outcomes of both women and men.PMID:33706641 | DOI:10.1080/1...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Authors: Source Type: research