PDTC ameliorates neuropathic pain by inhibiting microglial activation < em > via < /em > blockage of the TNF α-CX3CR1 pathway

In conclusion, intrathecal infusion of PDTC could attenuate the pain-related behaviors induced by sciatic nerve CCI through suppressing the spinal microglia activation and TNF-a up-regulation in rats. The NF- κB activation might be responsible for TNF-a-induced CX3CR1 up-regulation in microglia.

Source: European Journal of Histochemistry - January 20, 2021 Category: Biomedical Science Authors: Xilei Li, Zhi Ye, Qulian Guo, E Wang, Yundan Pan Source Type: research