Deep Brain Stimulation of the Internal Pallidum in Lesch –Nyhan Syndrome: Clinical Outcomes and Connectivity Analysis

ConclusionCombined bilateral stimulation of the anteromedial and posteroventral GPi may be considered as an option for managing refractory dystonia and self ‐harm behavior in LNS patients. A multidisciplinary team‐based approach is essential for patient selection and management, to support children and families, to achieve functional improvement and alleviate the overall disease burden for patients and caregivers.

Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Kantharuby Tambirajoo, Luciano Furlanetti, Harutomo Hasegawa, Ahmed Raslan, Hortensia Gimeno, Jean ‐Pierre Lin, Richard Selway, Keyoumars Ashkan Tags: Clinical Research Source Type: research