Anaplastic lymphoma kinase inhibitor NVP ‑TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells

In conclusion, the findings of the present study indicated that NVP‑TAE684 exerted its antitumor effects by inducing G2/M arrest and apoptosis via the inhibition of the ALK signaling pathway, and suggests its potential use as an antitumor agent against pancreatic adenocarcinoma.PMID:33649854 | DOI:10.3892/or.2021.7979

Source: Oncology Reports - March 2, 2021 Category: Cancer & Oncology Authors: Hong-Quan Duong Van Thai Than Huyen-Trang Nguyen Phuong-Thoa Nguyen Huyen Trang Ha Thi Thi Ngoc Ha Bui Vu Phuong Linh Dang Thi-Thanh Dinh Kyu Sic You The-Hung Dang Yeon-Sun Seong Source Type: research