High-Flow Nasal Cannula, a Boon or a Bane for COVID-19 Patients? An Evidence-Based Review

AbstractPurpose of ReviewThis review instantiates the efficacy and safety of HFNC in the context of COVID-19 pandemic.Recent FindingsGlobally, the healthcare system is facing an unprecedented crisis of resources due to the 2019 novel coronavirus disease (COVID-19) pandemic. Fever, cough, dyspnea, myalgia, fatigue, and pneumonia are the most common symptoms associated with it. The incidence of invasive mechanical ventilation in ICU patients ranges from 29.1 to 89.9%. Supplemental oxygen therapy is the main stay treatment for managing hypoxemic respiratory failure. The high-flow nasal cannula (HFNC) is a novel non-invasive strategy for better oxygenation and ventilation in critically ill patients. In this grim scenario, a reduction in mechanical ventilation by means of HFNC is of prime interestSummaryHFNC is considered an aerosol-generating intervention with the risk of viral aerosolization with a concern of potential nosocomial transmission of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). However, there is no consensus regarding the use of HFNC in novel coronavirus-infected pneumonia (NCIP). HFNC seems to be an effective and safe treatment modality in acute respiratory failure with optimal settings and selection of ideal patients.
Source: Current Anesthesiology Reports - Category: Anesthesiology Source Type: research

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In conclusion, we highlighted the pivotal role of zinc in antiviral immunity and we suggested the bioactive molecules derived from medicinal plants as a search matrix for the development of anti-SARS-CoV-2 drugs.PMID:34602868 | PMC:PMC8483924 | DOI:10.1155/2021/9632034
Source: The Scientific World Journal - Category: Science Authors: Source Type: research
Int Immunopharmacol. 2021 Sep 13;100:108150. doi: 10.1016/j.intimp.2021.108150. Online ahead of print.ABSTRACTThe etiological agent of coronavirus disease (COVID-19) is the new member of the Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2), responsible for the pandemic that is plaguing the world. The single-stranded RNA virus is capable of infecting the respiratory tract, by binding the spike (S) protein on its viral surface to receptors for the angiotensin II-converting enzyme (ACE2), highly expressed in the pulmonary tissue, enabling the interaction of the virus with alveolar epi...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research
AbstractPurposeRecently coronavirus disease (COVID-19) caused a global pandemic, characterized by acute respiratory distress syndrome (ARDS). The aim of our study was to detect pulmonary embolism (PE) in patients with severe form of COVID-19 infection using pulmonary CT angiography, and its associations with clinical and laboratory parameters.MethodsFrom March to December 2020, we performed a prospective monocentric study collecting data from 374 consecutive patients with confirmed SARS-CoV-2 infection, using real-time reverse-transcriptase polymerase-chain-reaction (rRT-PCR) assay of nasopharyngeal swab specimens. We subs...
Source: La Radiologia Medica - Category: Radiology Source Type: research
In December 2019, with pneumonia-like clinical manifestations, a new severe acute respiratory syndrome coronavirus 2 emerged and quickly escalated into a pandemic. Since the first case detected in early March of last year, 8668 have died with an infection mortality rate of 1.52%, as of March 20, 2021. Bangladesh has been struck by the 2nd wave from mid-march 2021. As data on the second wave are sparse, the present study observed the demographic profile, symptoms, and outcomes of Coronavirus Disease 2019 (COVID-19) patients during this wave. The study was conducted at Sheikh Russel National Gastroliver Institute on 486 a...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
AbstractPurposeRecently coronavirus disease (COVID-19) caused a global pandemic, characterized by acute respiratory distress syndrome (ARDS). The aim of our study was to detect pulmonary embolism (PE) in patients with severe form of COVID-19 infection using pulmonary CT angiography, and its associations with clinical and laboratory parameters.MethodsFrom March to December 2020, we performed a prospective monocentric study collecting data from 374 consecutive patients with confirmed SARS-CoV-2 infection, using real-time reverse-transcriptase polymerase-chain-reaction (rRT-PCR) assay of nasopharyngeal swab specimens. We subs...
Source: La Radiologia Medica - Category: Radiology Source Type: research
S Simsek Uzunoglu, H AkcaNigerian Journal of Clinical Practice 2021 24(9):1259-1267 Coronavirus disease 2019 (COVID-19) caused by the new [novel] coronavirus, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a pandemic with exceeding 72 million cases and 1.2 million deaths by the end of November 2020. We aimed to evaluate clinical, laboratory, and radiology findings of COVID-19 in children as reported worldwide and thereby to increase the clinical knowledge about the disease. Bibliographic searches were conducted in December 2020 using PubMed and Google Scholar. The search was limited to children [...
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
Coronavirus disease 2019 (COVID-19), an acute respiratory illness caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a terrible worldwide pandemic since December 2019. As of late August 2021, over 210 million people have contracted COVID-19, with over 4.4 million deaths globally (see https://coronavirus.jhu.edu/map.html). Typical presentations of this infection include fever, cough, fatigue, pneumonia, and loss of taste or smell.1 Although relatively less common than respiratory symptoms, gastrointestinal symptoms including anorexia, diarrhea, vomiting, and abdominal discomfort occur in ...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Commentary Source Type: research
World J Gastroenterol. 2021 Aug 7;27(29):4763-4783. doi: 10.3748/wjg.v27.i29.4763.ABSTRACTThe emergence and rapid spread of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 180 million confirmed cases resulting in over 4 million deaths worldwide with no clear end in sight for the coronavirus disease 19 (COVID-19) pandemic. Most SARS-CoV-2 exposed individuals experience mild to moderate symptoms, including fever, cough, fatigue, and loss of smell and taste. However, many individuals develop pneumonia, acute respiratory distress syndrome, septic shock, and multiorgan dysfunction. In addition...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Source Type: research
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, keeps spreading globally. Evidence suggests that a subgroup of patients with severe symptomatology might have cytokine storms, which increases mortality. The use of interleukin-6 (IL-6) inhibitors may help in controlling the pathological immune response to the virus. Tocilizumab, a monoclonal antibody against IL-6, stands as an optional treatment for COVID-19 patients presenting this inflammatory hyper-response. We conducted a retrospective, observational, cohort study including 50 patients affected by COVID-19 w...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
THE CURRENT pandemic stemming from severe acute respiratory syndrome –related coronavirus-2 began in December 2019 with an outbreak of pneumonia in Wuhan, China.1,2 Since the initial cases, the outbreak has spread rapidly around the world, presenting health care systems with a global health crisis. This enveloped virus has an incubation period up to 14 days and pro duces a spectrum of clinical disease in humans.3 It can vary from mild upper respiratory tract infection with fever and cough to severe acute respiratory distress syndrome that may progress to sepsis and multiorgan failure.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
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