Elevated P-Selectin in Severe Covid-19: Considerations for therapeutic options

CONCLUSION:Elevation of P-selectin suggests a central role of platelet endothelium interaction as part of the multifaced pathogenic mechanism of COVID-19 leading to the local activation of hemostatic system forming pulmonary thrombi. Further work is necessary to determine the therapeutic role of antiplatelets agents or of the anti P-selectin antibody Crizanlizumab.

Source: Mediterranean Journal of Hematology and Infectious Diseases - February 26, 2021 Category: Hematology Authors: Chiara Agrati, Veronica Bordoni, alessandra sacchi, germana grassi, nicola petrosillo, emanuele nicastri, franca del nonno, giampiero d ' offizi, fabrizio palmieri, luisa marchioni, maria rosaria capobianchi, andrea antinori, giuseppe ippolito, Michele Bi Source Type: research