Are sensory neurons exquisitely sensitive to interleukin 1 β?

AbstractPeripheral nerve injury frequently evokes chronic neuropathic pain. This is initiated by a transient inflammatory response that leads to persistent excitation of dorsal root ganglion (DRG) neurons by inflammatory cytokines such as interleukin 1 β (IL-1β). In non-neuronal cells such as lymphocytes, interleukin 1 exerts actions at attomolar (aM; 10−18 M) concentrations. We now report that DRG neurons in defined-medium, neuron-enriched culture display increased excitability following 5–6 d exposure of 1aM IL-1β.

Source: Journal of Neuroimmunology - February 25, 2021 Category: Allergy & Immunology Authors: Patrick L. Stemkowski, Nataliya Bukhanova-Schulz, Troy Baldwin, Elena Posse de Chaves, Peter A. Smith Source Type: research