Chol-Dex nanomicelles: Synthesis, characterization and evaluation as efficient drug carriers for colon targeting

Carbohydr Res. 2021 Feb;500:108255. doi: 10.1016/j.carres.2021.108255. Epub 2021 Jan 31.ABSTRACTCore-shell structures obtained from amphiphilic molecules on self-assembly in a medium have emerged as an important tool in the area of biomedical sciences. Here, we have synthesized cholesteryl-dextran (Chol-Dex) amphiphiles in sufficiently high yields via conjugation of cholesteryl hemisuccinate to dextran in two different concentrations (5 and 10%). After physicochemical and spectral analysis, the nanomicelles were subjected to size measurements. DLS and TEM confirmed the formation of core-shell type of nanomicelles. Hydrophobic drug-entrapped formulations (Metronidazole and Rifampicin) displayed sustained release behaviour of drugs from them. Sustained release at neutral pH demonstrated usefulness of the non-toxic delivery system for colon specific diseases.PMID:33556844 | DOI:10.1016/j.carres.2021.108255
Source: Carbohydrate Research - Category: Genetics & Stem Cells Authors: Source Type: research