Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy

The structural engineering of layered MoO3 and WO3 nanostructures is reported here to activate their NIR ‐II absorption for efficient photothermal cancer therapy. The MoO3 −x nanobelts can be used as a robust nanoagent for photoacoustic imaging ‐guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication in the NIR‐II window. AbstractLayered metal oxides including MoO3 and WO3 have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near ‐infrared (NIR) absorption and thus are inefficient for photo‐induced biomedical applications. Herein, the structural engineering of layered MoO3 and WO3 nanostructures is first reported to activate their NIR ‐II absorption for efficient photothermal cancer therapy in the NIR‐II window. White‐colored micrometre‐long MoO3 nanobelts are transformed into blue ‐colored short, thin, defective, interlayer gap‐expanded MoO3 −x nanobelts with a strong NIR ‐II absorption via the simple lithium treatment. The blue MoO3 −x nanobelts exhibit a large extinction coefficient of 18.2  L g−1 cm−1 and high photothermal conversion efficiency of 46.9% at 1064  nm. After surface modification, the MoO3 −x nanobelts can be used as a robust nanoagent for photoacoustic imaging ‐guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication...
Source: Small - Category: Nanotechnology Authors: Tags: Research Article Source Type: research