Estimating the causal effect of BMI on mortality risk in people with heart disease, diabetes and cancer using Mendelian randomization

Observational data have reported that being overweight or obese, compared to being normal weight, is associated with a lower risk for death - the “obesity paradox”. We used Mendelian randomization (MR) to estimate causal effects of body mass index (BMI) on mortality risks in people with coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) or malignancy in whom this paradox has been often reported.

Source: International Journal of Cardiology - February 13, 2021 Category: Cardiology Authors: David A. Jenkins, Kaitlin H. Wade, David Carslake, Jack Bowden, Naveed Sattar, Ruth J.F. Loos, Nicholas J. Timpson, Matthew Sperrin, Martin K. Rutter Source Type: research