Mast Cells Are the Trigger of Small Vessel Disease and Diastolic Dysfunction in Diabetic Obese Mice.

CONCLUSIONS: Cardiac small vessel disease is a key mechanism of heart failure with preserved ejection fraction pathophysiology that can be targeted to prevent the occurrence of diastolic dysfunction, by using both mast cell stabilizers and antihistaminic drugs.
PMID: 33567863 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 11, 2021 Category: Cardiology Authors: Guimbal S, Cornuault L, Rouault P, Hollier PL, Chapouly C, Bats ML, Imbault J, Gadeau AP, Couffinhal T, Renault MA Tags: Arterioscler Thromb Vasc Biol Source Type: research