Cellular Therapies for Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a subtype of B-cell non-Hodgkin lymphoma (NHL) characterized by the presence of t(11;14) (q13;q32) translocation, resulting in overexpression of cyclin D11, 2. MCL commonly presents in the seventh decade of life (median age 65 years) with a heterogeneous clinical presentation2. The 2016 World Health Organization updated classification of the lymphoid neoplasms identifies 2 major MCL clinical entities, namely the classical or conventional MCL (cMCL), and the leukemic non-nodal MCL (nnMCL)3.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research