A peptide of the amino-terminus of GRK2 induces hypertrophy and yet elicits cardioprotection after pressure overload

G protein-coupled receptor (GPCR) kinase 2 (GRK2) expression and activity are elevated early on in response to several forms of cardiovascular stress and are a hallmark of heart failure. Interestingly, though, in addition to its well-characterized role in regulating GPCRs, mounting evidence suggests a GRK2 “interactome” that underlies a great diversity in its functional roles. Several such GRK2 interacting partners are important for adaptive and maladaptive myocyte growth; therefore, an understanding of domain-specific interactions with signaling and regulatory molecules could lead to novel target s for heart failure therapy.

Source: Journal of Molecular and Cellular Cardiology - February 3, 2021 Category: Cytology Authors: Kamila M. Bledzka, Iyad H. Manaserh, Jessica Grondolsky, Jessica Pfleger, Rajika Roy, Erhe Gao, J. Kurt Chuprun, Walter J. Koch, Sarah M. Schumacher Source Type: research