Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis.

In conclusion, our results clearly show that Importin β1 mediates the translocation of NF-κB into the nuclei of myeloma cells, thereby regulating proliferation and blocking apoptosis, which provides new insights for targeted myeloma therapies. PMID: 25643631 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25643631?dopt=Abstract

Source: Cellular Signalling - January 30, 2015 Category: Cytology Authors: Yan W, Li R, He J, Du J, Hou J Tags: Cell Signal Source Type: research