Synthesis, antiviral, DFT and molecular docking studies of some novel 1,2,4-triazine nucleosides as potential bioactive compounds.

Synthesis, antiviral, DFT and molecular docking studies of some novel 1,2,4-triazine nucleosides as potential bioactive compounds.
Carbohydr Res. 2021 Jan 22;500:108246
Authors: Khodair AI, El-Barbary AA, Imam DR, Kheder NA, Elmalki F, Ben Hadda T
Abstract
A novel series of nucleosides with potential antiviral activity have been synthesized and characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the synthesized compounds was assessed against the Coxsackie B virus and Hepatitis A virus (HAV-10). The results revealed that compound 6 is equipotent to the standard drug Ribavirin against HAV-10. Also, some computational studies, such as the prediction of pharmacokinetic properties, toxicity, and bioactivity, have been done.
PMID: 33516074 [PubMed - as supplied by publisher]

Source: Carbohydrate Research - January 22, 2021 Category: Genetics & Stem Cells Authors: Khodair AI, El-Barbary AA, Imam DR, Kheder NA, Elmalki F, Ben Hadda T Tags: Carbohydr Res Source Type: research