Cerebrospinal fluid biomarkers of glial and axonal injury in cervical spondylotic myelopathy.

CONCLUSIONS: CSF biomarkers of glial and axonal damage, inflammation, and synaptic changes are altered in symptomatic CSM patients, indicating that axonal injury, astroglial activation, and Aβ dysmetabolism may be present in these individuals. These findings reflect CSM pathophysiology and may aid in prognostication. However, future studies including larger patient cohorts, postoperative biomarker data and imaging, and longer follow-up times are required to validate the present findings.
PMID: 33513577 [PubMed - as supplied by publisher]

Source: Journal of Neurosurgery.Spine - January 29, 2021 Category: Neurosurgery Authors: Tsitsopoulos PP, Holmström U, Blennow K, Zetterberg H, Marklund N Tags: J Neurosurg Spine Source Type: research