Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci.

Conclusions: Here we describe unprecedented genome-wide open chromatin profiles from human pathogenic and non-pathogenic MVs and report specific gene regulation profiles, compared to the heart. We also report in vitro functional evidence for potential causal variants and target genes at MVP risk loci involving established and new biological mechanisms.
PMID: 33508947 [PubMed - as supplied by publisher]

Source: Circulation Research - January 28, 2021 Category: Cardiology Authors: Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras K, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N Tags: Circ Res Source Type: research