The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.

The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.
Circ Res. 2021 Jan 22;128(2):287-303
Authors: Nayor M, Brown KJ, Vasan RS
Abstract
Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.
PMID: 33476202 [PubMed - in process]

Source: Circulation Research - January 22, 2021 Category: Cardiology Authors: Nayor M, Brown KJ, Vasan RS Tags: Circ Res Source Type: research