Deciphering time-dependent DNA damage complexity, repair and oxygen tension: a mechanistic model for FLASH-dose-rate radiotherapy

Irradiation with ultra-high dose-rates (FLASH) has reemerged as a promising radiotherapy approach to effectively lower potential damage burden on normal tissue without sacrificing tumor control; however, the large number of recent FLASH studies are conducted under vastly different experimental conditions and circumstances i.e. investigated biological endpoint, radiation quality and environmental oxygen level, with unverified biological mechanisms of action and unexplored interplay effect of the main dependencies.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research