Ameliorative Impact of Aloe vera on Cartap Mediated Toxicity in the Brain of Wistar Rats

AbstractExposure to pesticides can pose a greater threat to multiple organs of nontarget animals. Cartap is a thiocarbamate pesticide, broadly used in agricultural fields. The assessment of neurotoxicity of cartap has not been properly studied in the mammalian systems. The present investigation unveils the toxic effects of cartap in the brain of Wistar rats its amelioration by using aqueous extract ofAloe vera leaves. We have used 4 groups of animals comprising six in each: Group 1- control, Group 2- control withAloe vera, Group 3- cartap, Group 4- cartap withAloe vera treated. After 15  days of treatment, biochemical investigations were conducted. Wistar rats orally exposed to sublethal doses of cartap, showed significant variations in the levels of prooxidants i.e. MDA and GSH (an oxidative stress marker) and enzymatic antioxidants i.e. SOD, CAT, GST, GPx. The decreased levels o f CAT, SOD, GST and increased levels of GPx were detected in the experimental rats treated with cartap. The significant alterations were recorded with the declined activities of LDH and AChE, considered as the biomarker of energy metabolism and altered cholinergic function, respectively. However, th e pre-administration of aqueous extract ofAloe vera leaves was found to markedly ameliorate the toxic effects of cartap by shielding the levels of aforesaid oxidative markers near to the control. The ameliorative impact ofAloe vera, might be due to the presence of several antioxidant molecules in it whi...

Source: Indian Journal of Clinical Biochemistry - January 3, 2021 Category: Biochemistry Source Type: research