Blockade of sodium ‑calcium exchanger via ORM-10962 attenuates cardiac alternans
Repolarization alternans, a periodic oscillation of long-short action potential duration, is an important source of arrhythmogenic substrate, although the mechanisms driving it are insufficiently understood. Despite its relevance as an arrhythmia precursor, there are no successful therapies able to target it specifically. We hypothesized that blockade of the sodium ‑calcium exchanger (NCX) could inhibit alternans. The effects of the selective NCX blocker ORM-10962 were evaluated on action potentials measured with microelectrodes from canine papillary muscle preparations, and calcium transients measured using Fluo4-AM from isolated ventricular myocytes paced to evoke alternans.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Jozefina Szlov ák, Jakub Tomek, Xin Zhou, Noémi Tóth, Roland Veress, Balázs Horváth, Norbert Szentandrássy, Jouko Levijoki, Julius Gy. Papp, Neil Herring, András Varró, David A. Eisner, Blanca Rodriguez, Norbert Nagy Source Type: research