Mechanisms underlying age-associated manifestation of cardiac sodium channel gain-of-function

Cardiac action potentials are initiated by sodium ion (Na+) influx through voltage-gated Na+ channels. Na+ channel gain-of-function (GOF) can arise in inherited conditions due to mutations in the gene encoding the cardiac Na+ channel, such as Long QT syndrome type 3 (LQT3). LQT3 can be a “concealed” disease, as patients with LQT3-associated mutations can remain asymptomatic until later in life; however, arrhythmias can also arise early in life in LQT3 patients, demonstrating a complex age-associated manifestation.

Source: Journal of Molecular and Cellular Cardiology - December 26, 2020 Category: Cytology Authors: Madison B. Nowak, Steven Poelzing, Seth H. Weinberg Source Type: research