Pharmacokinetics and pharmacodynamics of tegoprazan co-administered with amoxicillin and clarithromycin in healthy subjects.

In conclusion, the exposure of tegoprazan was increased after co-administration of amoxicillin/clarithromycin, which led to increase pharmacodynamic response measured by intragastric pH compared to tegoprazan alone. Therefore, tegoprazan-based triple therapy would be effective therapeutic regimen to manage intragastric pH in terms of gastric or duodenal ulcers healing, treatment of gastroesophageal reflux disease, and Helicobacter pylori eradication. This article is protected by copyright. All rights reserved. PMID: 33341955 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: J Clin Pharmacol Source Type: research