Flavonoids from marine-derived actinobacteria as anticancer drugs.

Flavonoids from marine-derived actinobacteria as anticancer drugs. Curr Pharm Des. 2020 Dec 16;: Authors: Hozzein WN, Mohany M, Alhawsawi SMM, Zaky MY, Al-Rejaie SS, Alkhalifah DHM Abstract Flavonoids represent a large diverse group of natural products that are used as a traditional medicine against various infectious diseases. They possess many biological activities including antimicrobial, antioxidant, antiinflammatory, anti-cancer and anti-diabetic. Commercially Flavonoids are mainly obtained from plants, however, several challenges faced that production. Microorganisms have been known as natural sources of a wide range of bioactive compounds including flavonoids. Actinobacteria are the most prolific group of microorganisms for the production of bioactive secondary metabolites hold many advantages for the production of flavonoids. The screening programs for bioactive compounds revealed the potential application of actinobacteria to produce flavonoids with interesting biological activities, especially anticancer activities. Since marine actinobacteria are recognized as a potential source of novel anticancer agents, they are highly expected to be potential producers of anticancer flavonoids with unusual structures and properties. In this review, we highlight the production of flavonoids by actinobacteria through classical fermentation, engineering of plant biosynthetic genes in a recombinant actinobacterium and the de novo biosynthe...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research