Distinct clinicopathological features of pulmonary primary angiomatoid fibrous histiocytoma: A report of four new cases and review of the literature

ConclusionsPPAFH is a very unusual pulmonary primary mesenchymal tumor and the clinicopathological features are like other unusual sites counterparts, but with a smaller tumor size, related with large airway, with a tendency to exhibit benign biological behavior, withEWSR1 gene rearrangement and higher frequency ofEWSR1 ‐CREB1 gene fusion.Key pointsSignificant findings in the study: In comparison with “classic somatic” and nonpulmonary visceral angiomatoid fibrous histiocytoma, pulmonary primary angiomatoid fibrous histiocytoma display distinct clinicopathological features and prognosis.What this study adds The study provided the pathological differential diagnostic criteria and clinico ‐pathological features for pulmonary primary angiomatoid fibrous histiocytoma.

Source: Thoracic Cancer - December 12, 2020 Category: Cancer & Oncology Authors: Zheng Wang, Liping Zhang, Li Ren, Dongge Liu, Jun Du, Min Zhang, Ge Lou, Ying Song, Yin Wang, Chunyan Wu, Guiping Han Tags: ORIGINAL ARTICLE Source Type: research