Molecular pathways of Interferon-Stimulated Gene 15: Implications in cancer.

Molecular pathways of Interferon-Stimulated Gene 15: Implications in cancer. Curr Protein Pept Sci. 2020 Dec 08;: Authors: Tecalco-Cruz AC Abstract Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokine-like protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types. PMID: 33292152 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33292152?dopt=Abstract

Source: Current Protein and Peptide Science - December 8, 2020 Category: Biochemistry Authors: Tecalco-Cruz AC Tags: Curr Protein Pept Sci Source Type: research