Circulatory miRNA-155, miRNA-21 target PTEN expression and activity as a factor in breast cancer development.

Circulatory miRNA-155, miRNA-21 target PTEN expression and activity as a factor in breast cancer development. Cell Mol Biol (Noisy-le-grand). 2020 Oct 31;66(7):44-50 Authors: Ali SA, Abdulrahman ZFA, Faraidun HN Abstract Breast cancer is a complex disease with multiple factors involved in its pathophysiological development. genetic mutations of BRCA1, BRCA2 and p53 are among the most well-studied factors. The role of other genetic factors like altered expression profiles, SNPs in the regulatory regions of different genes or epigenetic factors like promoter methylation and histone modifications are also well studied but no solid understanding is available on distinct key players triggering malignancy in breast cancer, (Phosphatase and tensin homolog) PTEN is known to be a crucial tumor suppressor as it has been reported to be missing or abnormally expressed in many cancer cells. Here in this were studied how PTEN is expressed in malignant and benign cancer cells by investigating its expression profile and cellular location using Immuno-fluorescence microscopy. At the same time, quantitative studies of the circulatory mi-RNAs related to the downregulation of PTEN, namely mir-21 and mir-155 have studied also. Sixty biopsy samples, forty were diagnosed to be malignant and twenty were benign. It has been found that PTEN is normally expressed in benign samples and its normally localized in the cell membrane, while in malignant samples the expression level of PT...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

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Background: In a previous exploratory study, we reported lower concentrations of the ovarian reserve biomarker anti-Müllerian hormone (AMH) in adulthood with prenatal farm exposure. We now examine this association as well as childhood farm exposure using enrollment data from the Sister Study, a large US cohort of women. Methods: We collected prenatal and childhood farm exposure data by questionnaire and telephone interview. However, serum AMH data were available only for a nested subset: premenopausal women ages 35–54 subsequently diagnosed with breast cancer (n = 418 cases) and their matched controls...
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Conditions:   Breast Cancer;   Sentinel Lymph Node Biopsy;   Neoadjuvant Therapy Intervention:   Procedure: SLNB + ALND Sponsor:   National Cheng-Kung University Hospital Active, not recruiting
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Conditions:   ER+ Breast Cancer;   HER2-negative Breast Cancer Interventions:   Drug: Palbociclib 125Mg Tab;   Drug: Fulvestrant injection;   Drug: Tamoxifen;   Drug: Letrozole;   Drug: Exemestane;   Drug: Anastrozole Sponsors:   Royal Marsden NHS Foundation Trust;   Pfizer;   AstraZeneca;   Institute of Cancer Research, United Kingdom;   UNICANCER;   Gustave Roussy, Cancer Campus, Grand Paris Not yet recruiting
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Condition:   Operable Breast Neoplasms Intervention:   Other: prediction of overall survival using Web based PREDICTV2.0 portal Sponsor:   Tata Memorial Centre Recruiting
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Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Authors: Source Type: research
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