Bacteriophages for ESKAPE: Role in pathogenicity and measures of control.

Bacteriophages for ESKAPE: Role in pathogenicity and measures of control. Expert Rev Anti Infect Ther. 2020 Dec 01;: Authors: Patil A, Banerji R, Kanojiya P, Koratkar S, Saroj S Abstract INTRODUCTION: The quest to combat bacterial infections has dreaded humankind for centuries. Infections involving ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) impose therapeutic challenges due to the emergence of antimicrobial drug resistance. Recently, investigations with bacteriophages have led to the development of novel strategies against ESKAPE infections. Also, bacteriophages have been demonstrated to be instrumental in the dissemination of virulence markers in ESKAPE pathogens. AREAS COVERED: The review highlights the potential of bacteriophage in and against the pathogenicity of antibiotic-resistant ESKAPE pathogens. The review also emphasizes the challenges of employing bacteriophage in treating ESKAPE pathogens and the knowledge gap in the bacteriophage mediated antibiotic resistance and pathogenicity in ESKAPE infections. EXPERT OPINION: Bacteriophage infection can kill the host bacteria but in survivors can transfer genes which contribute towards survival of the pathogens in the host and resistance towards multiple antimicrobials. The knowledge on the dual role of bacteriophages in the treatment and pathogenicity will assist ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research