Different Patterns of Gray Matter Volume Reduction in Early-onset and Late-onset Alzheimer Disease

Conclusion: MMSE total score is associated with the anterior temporal lobe volume in individuals with AD. Hippocampal volume and its relationship with MMSE total score are associated with LOAD pathophysiology but not EOAD pathophysiology. The hippocampal volume reduction and low MMSE scores are hallmarks of LOAD but are less specific to EOAD, which may cause a delay in diagnosis.
Source: Cognitive and Behavioral Neurology - Category: Neurology Tags: Original Study Source Type: research