AMD3100 re-dosing fails to repeatedly mobilize hematopoietic stem cells in the non-human primate and humanized mouse

Hematopoietic stem and progenitor cell (HSPC) transplantation constitutes the gold standard treatment for many malignant and non-malignant conditions. 1 Mobilization of HSPCs from the bone marrow (BM) niche into the peripheral blood (PB) circulation is a critical part of most autologous and allogeneic HSPC transplant protocols, facilitating HSPC collection from the circulation by apheresis.2,3 This avoids invasive BM harvest, with inherent risks of infection, bleeding, structural damage, and the need for a general anaesthetic.

Source: Experimental Hematology - December 1, 2020 Category: Hematology Authors: Clare Samuelson, Stefan Radtke, Margaret Cui, Anai Perez, Hans-Peter Kiem, Olivier Humbert Source Type: research