Potential emerging roles of the novel adipokines adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis interplay.

CONCLUSIONS: Metrnl, and to a lesser extent adipolin seem to be interrelated with OA. Different in-context regulatory mechanisms for metrnl production from various tissues are strongly suggested. Importantly, the findings of the current study shed lights on metrnl as a potential novel mediator and therapeutic target to consider in obesity-OA interplay.
PMID: 33248913 [PubMed - as supplied by publisher]

Source: Cytokine - November 25, 2020 Category: Molecular Biology Authors: Sobieh BH, Kassem DH, Zakaria ZM, El-Mesallamy HO Tags: Cytokine Source Type: research