The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid.

The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid. Br J Nutr. 2020 Nov 27;:1-23 Authors: Stoffel NU, Cepeda Lopez AC, Cervantes-Gracia K, Llanas-Cornejo D, Delgado González EA, Herter-Aeberli I, Zimmermann MB Abstract Although hepcidin synthesis is stimulated by inflammation and inhibited by iron deficiency, the strength of their opposing effects on serum hepcidin in humans remain unclear. It was recently shown that an inflammatory stimulus in anemic women did not increase serum hepcidin or decrease iron absorption. The enhancing effect of ascorbic acid on iron absorption may not be effective during inflammation, because of increased serum hepcidin. Our study aim was to test whether reducing inflammation in iron-depleted overweight women with low-grade inflammation would lower serum hepcidin and improve iron absorption with and without ascorbic acid, compared to normal-weight women without inflammation. Before and after 14d of anti-inflammatory treatment (3x600mg ibuprofen daily) in overweight and normal-weight women (n=36; age 19-46 y), we measured serum hepcidin and fractional iron absorption (erythrocyte iron incorporation) from 57Fe- and 58Fe-labeled test meals with and without ascorbic acid. There were significant group effects on interleukin (IL)-6, C-reactive protein, serum ferritin, and SHep (for all, p<0.05). There was a sign...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research