Prioritized Endpoints for Device-Based Hypertension Trials: the Win Ratio Methodology.

CONCLUSIONS: The win ratio method addresses prior limitations by enabling inclusion of more patient-oriented results while prioritizing those endpoints considered most clinically important. Applying these methods to the SPYRAL HTN-ON MED pilot study, RDN was determined superior regarding a hierarchical endpoint and a 'winner' compared with sham control patients. Classifications Renal sympathetic denervation, uncontrolled hypertension, clinical trials. PMID: 33226002 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research