Researchers pinpoint 2 genes that trigger severest form of ovarian cancer

(University of North Carolina Health Care) Researchers from the UNC School of Medicine create the first ever mouse model of ovarian clear cell carcinoma using data gleaned from the human cancer genome atlas. They show how when the genes ARID1A and PIK2CA are mutated in specific ways, the result is the most severe form of ovarian cancer 100 percent of the time. In their paper in Nature Communications, they also show that a known drug can suppress tumor growth.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news