Involvement of TACAN, a mechanotransducing ion channel, in inflammatory but not neuropathic hyperalgesia in the rat

Most clinical pain syndromes are associated with sensitization of nociceptors to mechanical stimuli, especially those pain syndromes associated with inflammation 33,42,44,46,54 and peripheral neuropathy 12,22,31,53. Mechanotransduction in sensory neurons is a vital process underlying several physiological functions, including hearing, touch, pain, and proprioception 14,18,41,61. The mechanisms underlying mechanotransduction in somatosensory neurons have only recently begun to be elucidated. Piezo2, a mechanotransducing ion channel is now well-established to contribute to the sensation of light touch 34,62, and may also contribute to some forms of nociception 37.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research