Development and biocompatibility analysis of NBD peptide sustained-release microsphere scaffold nanoparticle SP-Sr-CaS/NBD.

In this study, the small molecule NBD polypeptide and bone conduction matrix Sr-CaS are microsphere-formed to prepare Sr-CaS, NBD drug-loaded sustained-release micro-spheres, in order to achieve a Sr-CaS/NBD peptide drug-loaded sustained release microsphere scaffold material (SP-Sr-CaS/NBD). We prepared the microspheres and optimized the production process to obtain particles with stable morphologi-cal properties and sustained release properties. In vitro experiments demonstrated that SP-Sr-CaS/NBD can reduce TNF-α-induced cell growth inhibition, caspase-3 activity and NF-κB transcriptional activation as the function of continuous NBD peptide dosing regimen. Also, the introduction of Sr-CaS matrix potentiate microspheres to promote cell proliferation and provides a basis to become a hopeful used 3D bone scaffold material in the future.
PMID: 33198617 [PubMed - as supplied by publisher]

Source: Current Drug Delivery - November 16, 2020 Category: Drugs & Pharmacology Authors: Li X, Wang L, Wang C, Tan C, Liu X, Zhu Y Tags: Curr Drug Deliv Source Type: research