Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis

AbstractClassically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular classification of gliomas is associated with preoperative seizure presentation and/or post-operative seizure control across multiple glioma subtypes. All gliomas operated at our institution from 2007 to 2017 were identified based on ICD 9 and 10 billing codes and were retrospectively assessed for molecular classification of theIDH1 mutation, and1p/19q codeletion. Logistic regression models were performed to assess associations of seizures at presentation as well as post-operative seizures with IDH status and the new WHO integrated classification. Our study included 376 patients: 82 IDH mutant and 294 IDH wildtype. The presence ofIDH mutation was associated with seizures at presentation [OR 3.135 (1.818 –5.404),p <  0.001].IDH-mutant glioblastomas presented with seizures less often than otherIDH-mutant glioma subtypes grade II and III [OR 0.104 (0.032 –0.340),p <  0.001].IDH-mutant tumors were associated with worse post-operative seizure outcomes, demonstrated by Engel Class [OR 2.666 (1.592 –4.464),p <  0.001].IDH mutation in gliomas is associated with an increased risk of seizure development and worse post-operative seizure control,...
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research